1.   You start off with a Pikachu
2.  Your rival starts off eith an Eevee
3.  You will be able to battle Team Rocket (Jesse, James, and Meowth)
4.  You can catch Bulbasaur, Charmander, and Squirtle in the wild
5.  Cheats do not work in this version
6.  Pictures have been improved
7.  Pikachu follows you around
8.  Follows the plot of the show better than red or blue
9.  Pokemon evolve at different levels than they did in Red or Blue
10.  Some TM's won't work on the same pokemon that they did in Red or Blue